These can occur either inside the body or onits surface (skin or mucosa). These lesions are delicate and subject to rupture causing unpredictable and uncontrolled bleeding leading to chronic conditions such as iron deficiency and often requiring blood transfusions. One of the most prominent of all diseases caused by Vascular Malformations is known as HHT, or Hereditary Haemorrhagic Telangiectasia.
More than half of HHT patients suffer from lesions in the lung, brain and/or liver, sometimes resulting in life-threatening events such as pulmonary haemorrhage, stroke or brain abscess. There are no treatments approved to address this disease and patients currently rely on interventions which, at best, only manage their symptoms.